Glutathione 5-Transferases: Role in Alkylating Agent Resistance and Possible Target for Modulation Chemotherapy— A Review1
نویسنده
چکیده
The effectiveness of many clinically useful anticancer drugs can be severely limited by drug resistance, which appears to be intrinsic to some tumors but can also arise during multiple courses of chemotherapy in the case of many others. Studies carried out using cultured tumor cell models and other systems have established that a variety of mechanisms can contribute to drug resistance (1-3). These include alterations in drug uptake or drug efflux from the cell [transporter defects, P-glycoprotein (Mdr) overexpression], changes in drug-metabolizing enzymes [e.g., aldehyde dehydrogenase (cyclophosphamide), folylpolyglutamate synthetase (methotrexate), metallothionein (cisplatin)], and changes in target enzymes [dihydrofolate reducÃ-ase (methotrexate), topoisomerase II (etoposide, teniposide), and enzymes of DNA repair [O6-methylguanine alkyltransferase].
منابع مشابه
Class-Pi of Glutathione S-Transferases
Class-Pi of glutathione s-transferases (GST-Pi) is the specific form of GSTs that are known to participate particularly in the mechanisms of resistance to drugs and carcinogens. This class of the enzyme is referred to as class-P or class-Pi or class π. The accepted terminology in this review article is class-Pi. In this article following a brief description of identified molecular forms of GSTs...
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